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1

Expression of Fas antigen is not associated with apoptosis in human myopathies

Akira Inukai, Yasushi Kobayashi, Keita Ito, Manabu Doyu, Akemi Takano, Hitoshi Honda, Gen Sobue

Journal:

Year:

1997

Language:

english

File:

PDF, 350 KB

english, 1997

2

Expression of HLA-DR and its enhancing molecules in muscle fibers in polymyositis

Akira Inukai, Satosi Kuru, Yideng Liang, Akemi Takano, Yasushi Kobayashi, Motoko Sakai, Manabu Doyu, Gen Sobue

Journal:

Year:

2000

Language:

english

File:

PDF, 363 KB

english, 2000

3

Reduced expression of DMAHP/SIX5 gene in myotonic dystrophy muscle

Akira Inukai, Manabu Doyu, Takashi Kato, Yideng Liang, Satosi Kuru, Masahiko Yamamoto, Yasushi Kobayashi, Gen Sobue

Journal:

Year:

2000

Language:

english

File:

PDF, 345 KB

english, 2000

4

Human peripheral nerve sheath neoplasm: Expression of Schwann cell-related markers and their relation to malignant transformation

Dr., MD Takeshi Yasuda, Dr., Dr. Gen Sobue, Dr., MD Takayuki Ito, Dr., MD Manabu Doyu, Dr., MD Isao Sugiura, Dr., MD Yoshio Hashizume, Dr., MD Kanefusa Kato

Journal:

Year:

1991

Language:

english

File:

PDF, 828 KB

english, 1991

5

Primary sensory neurons in x-linked recessive bulbospinal neuronopathy: Histopathology and androgen receptor gene expression

Mei Li, Gen Sobue, Manabu Doyu, Eiichiro Mukai, Yoshio Hashizume, Terunori Mitsuma

Journal:

Year:

1995

Language:

english

File:

PDF, 932 KB

english, 1995

6

X-Linked recessive bulbospinal neuronopathy: Clinical phenotypes and cag repeat size in androgen receptor gene

Noriko Shimada, Dr. Gen Sobue, Manabu Doyu, Koji Yamamoto, Takeshi Yasuda, Eiichiro Mukai, Teruhiko Kachi, Terunori Mitsuma

Journal:

Year:

1995

Language:

english

File:

PDF, 617 KB

english, 1995

7

Mutations in the peripheral myelin protein zero and connexin32 genes detected by non-isotopic RNase cleavage assay and their phenotypes in Japanese patients with Charcot-Marie-Tooth disease

Tsuyoshi Yoshihara, Masahiko Yamamoto, Manabu Doyu, Ken-Ichiro Mis, Naoki Hattori, Yasuhiro Hasegawa, Kenji Mokuno, Terunori Mitsuma, Gen Sobue

Journal:

Year:

2000

Language:

english

File:

PDF, 75 KB

english, 2000

8

Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin: A pathogenic marker

Haruhiko Banno, Hiroaki Adachi, Masahisa Katsuno, Keisuke Suzuki, Naoki Atsuta, Hirohisa Watanabe, Fumiaki Tanaka, Manabu Doyu, Gen Sobue

Journal:

Annals of Neurology

Year:

2006

Language:

english

File:

PDF, 1023 KB

english, 2006

9

Severity of X-linked recessive bulbospinal neuronopathy correlates with size of the tandem cag repeat in androgen receptor gene

Manabu Doyu, Dr. Gen Sobue, Eiichiro Mukai, Teruhiko Kachi, Takeshi Yasuda, Terunori Mitsuma, Akira Takahashi

Journal:

Annals of Neurology

Year:

1992

Language:

english

File:

PDF, 405 KB

english, 1992

10

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

Mei Li, Shigeru Miwa, Yasushi Kobayashi, Diane E. Merry, Masahiko Yamamoto, Fumiaki Tanaka, Manabu Doyu, Yoshio Hashizum, Kenneth H. Fischbeck, Dr. Gen Sobue

Journal:

Annals of Neurology

Year:

1998

Language:

english

File:

PDF, 2.27 MB

english, 1998

11

Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis

Jun Sone, Jun-ichi Niwa, Kaori Kawai, Shinsuke Ishigaki, Shin-ichi Yamada, Hiroaki Adachi, Masahisa Katsuno, Fumiaki Tanaka, Manabu Doyu, Gen Sobue

Journal:

Journal of Neuroscience Research

Year:

2010

Language:

english

File:

PDF, 1.56 MB

english, 2010

12

Detection of Triplet Repeat Expansion in the Human Genome by Use of Hybridization Signal Intensity

Ko-ichi Sawada, Manabu Doyu, Fumiaki Tanaka, Gen Sobue, Kikuya Kato

Journal:

Analytical Biochemistry

Year:

2000

Language:

english

File:

PDF, 274 KB

english, 2000

13

Sisters homozygous for the spinocerebellar ataxia type 6 (SCA6)/CACNA1A gene associated with different clinical phenotypes

Takeshi Kato, Fumiaki Tanaka, Masahiko Yamamoto, Eiji Yosida, Toshikatsu Indo, Hidetaka Watanabe, Tsuyoshi Yoshiwara, Manabu Doyu, Gen Sobue

Journal:

Clinical Genetics

Year:

2000

Language:

english

File:

PDF, 172 KB

english, 2000

14

Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis

Tsuyoshi Yoshihara, Shinsuke Ishigaki, Masahiko Yamamoto, Yideng Liang, Jun, Ichi Niwa, Hideyuki Takeuchi, Manabu Doyu, Gen Sobue

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 415 KB

english, 2002

15

X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration

Shinsuke Ishigaki, Yideng Liang, Masahiko Yamamoto, Jun-ichi Niwa, Yoshio Ando, Tsuyoshi Yoshihara, Hideyuki Takeuchi, Manabu Doyu, Gen Sobue

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 383 KB

english, 2002

16

Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis

Hideyuki Takeuchi, Jun-ichi Niwa, Nozomi Hishikawa, Shinsuke Ishigaki, Fumiaki Tanaka, Manabu Doyu, Gen Sobue

Journal:

Journal of Neurochemistry

Year:

2004

Language:

english

File:

PDF, 541 KB

english, 2004

17

Extensive demyelinating changes in the peripheral nerves of Crow-Fukase syndrome: a pathological study of one autopsied case

G. Sobue, M. Doyu, M. Watanabe, F. Hayashi, T. Mitsuma

Journal:

Acta Neuropathologica

Year:

1992

Language:

english

File:

PDF, 2.26 MB

english, 1992

18

Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein

Masahiro Waza, Hiroaki Adachi, Masahisa Katsuno, Makoto Minamiyama, Fumiaki Tanaka, Manabu Doyu, Gen Sobue

Journal:

Journal of Molecular Medicine

Year:

2006

Language:

english

File:

PDF, 403 KB

english, 2006

19

The role of lymphotoxin in pathogenesis of polymyositis

Yideng Liang, Akira Inukai, Satosi Kuru, Takashi Kato, Manabu Doyu, G. Sobue

Journal:

Acta Neuropathologica

Year:

2000

Language:

english

File:

PDF, 170 KB

english, 2000

20

Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer’s disease brain

Akinori Takeda, Takeshi Yasuda, Toshio Miyata, Yoji Goto, Masakazu Wakai, Masaki Watanabe, Yoshinari Yasuda, Katsunori Horie, Toshiaki Inagaki, Manabu Doyu, Kenji Maeda, G. Sobue

Journal:

Acta Neuropathologica

Year:

1998

Language:

english

File:

PDF, 381 KB

english, 1998

21

Tumor necrosis factor-α expression in muscles of polymyositis and dermatomyositis

S. Kuru, A. Inukai, Y. Liang, M. Doyu, A. Takano, G. Sobue

Journal:

Acta Neuropathologica

Year:

2000

Language:

english

File:

PDF, 177 KB

english, 2000

22

Low cardiac123I-MIBG uptake in late-onset familial amyloid polyneuropathy type I (TTR Met30)

H. Watanabe, K. Misu, M. Hirayama, N. Hattori, T. Yoshihara, M. Doyu, G. Sobue

Journal:

Journal of Neurology

Year:

2001

Language:

english

File:

PDF, 107 KB

english, 2001

23

Differential somatic CAG repeat instability in variable brain cell lineage in dentatorubral pallidoluysian atrophy (DRPLA): a laser-captured microdissection (LCM)-based analysis

Hidetaka Watanabe, Fumiaki Tanaka, Manabu Doyu, Shigeo Riku, Mari Yoshida, Yoshio Hashizume, Gen Sobue

Journal:

Year:

2000

Language:

english

File:

PDF, 259 KB

english, 2000

24

Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy

H. Adachi, M. Waza, M. Katsuno, F. Tanaka, M. Doyu, G. Sobue

Journal:

Neuropathology and Applied Neurobiology

Year:

2007

Language:

english

File:

PDF, 405 KB

english, 2007

25

Frequency analysis of autosomal dominant cerebellar ataxias in Japanese patients and clinical characterization of spinocerebellar ataxia type 6

Hidetaka Watanabe, Fumiaki Tanaka, Michiyo Matsumoto, Manabu Doyu, Tetsuo Ando, Terunori Mitsuma, Gen Sobue

Journal:

Clinical Genetics

Year:

1998

Language:

english

File:

PDF, 995 KB

english, 1998

26

Laminin A, B1, and B2 Chain Gene Expression in Transected and Regenerating Nerves: Regulation by Axonal Signals

Manabu Doyu, Gen Sobue, Eishuku Ken, Koji Kimata, Tamayuki Shinomura, Yoshihiko Yamada, Terunori Mitsuma, Akira Takahashi

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 1.22 MB

english, 1993

27

Unique features of the CAG repeats in Machado–Joseph disease

Kawakami, Hideshi, Maruyama, Hirofumi, Nakamura, Shigenobu, Kawaguchi, Yoshiya, Kakizuka, Akira, Doyu, Manabu, Sobue, Gen

Journal:

Nature Genetics

Year:

1995

File:

PDF, 178 KB

1995

28

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

Waza, Masahiro, Adachi, Hiroaki, Katsuno, Masahisa, Minamiyama, Makoto, Sang, Chen, Tanaka, Fumiaki, Inukai, Akira, Doyu, Manabu, Sobue, Gen

Journal:

Nature Medicine

Year:

2005

Language:

english

File:

PDF, 405 KB

english, 2005

29

Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

Katsuno, Masahisa, Adachi, Hiroaki, Doyu, Manabu, Minamiyama, Makoto, Sang, Chen, Kobayashi, Yasushi, Inukai, Akira, Sobue, Gen

Journal:

Nature Medicine

Year:

2003

Language:

english

File:

PDF, 993 KB

english, 2003

30

Gene Expression Profiling toward Understanding of ALS Pathogenesis

FUMIAKI TANAKA, JUN-ICHI NIWA, SHINSUKE ISHIGAKI, MASAHISA KATSUNO, MASAHIRO WAZA, MASAHIKO YAMAMOTO, MANABU DOYU, GEN SOBUE

Journal:

Annals of the New York Academy of Sciences

Year:

2006

Language:

english

File:

PDF, 197 KB

english, 2006

31

Temporal Expression of mRNAs for Neuropoietic Cytokines, Interleukin-11 (IL-11), Oncostatin M (OSM), Cardiotrophin-1 (CT-1) and Their Receptors (IL-11Rα and OSMRβ) in Peripheral Nerve Injury

Yasuhiro Ito, Masahiko Yamamoto, Mei Li, Norimasa Mitsuma, Fumiaki Tanaka, Manabu Doyu, Akio Suzumura, Terunori Mitsuma, Gen Sobue

Journal:

Neurochemical Research

Year:

2000

Language:

english

File:

PDF, 49 KB

english, 2000

32

Expression of mRNAs for Neurotrophins (NGF, BDNF, and NT-3) and their Receptors (p75NGFR, Trk, TrkB, and TrkC) in Human Peripheral Neuropathies

Gen Sobue, Masahiko Yamamoto, Manabu Doyu, Mei Li, Takeshi Yasuda, Terunori Mitsuma

Journal:

Neurochemical Research

Year:

1998

Language:

english

File:

PDF, 1.47 MB

english, 1998

33

Somatic Mosaicism of the Expanded CAG Trinucleotide Repeat in mRNAs for the Responsible Gene of Machado-Joseph Disease (MJD), Dentatorubral-Pallidoluysian Atrophy (DRPLA), and Spinal and Bulbar Muscular Atrophy (SBMA)

Yasuhiro Ito, Fumiaki Tanaka, Masahiko Yamamoto, Manabu Doyu, Masaaki Nagamatsu, Shigeo Riku, Terunori Mitsuma, Gen Sobue

Journal:

Neurochemical Research

Year:

1998

Language:

english

File:

PDF, 2.34 MB

english, 1998

34

Caspase-1 and -3 mRNAs Are Differentially Upregulated in Motor Neurons and Glial Cells in Mutant SOD1 Transgenic Mouse Spinal Cord: A Study Using Laser Microdissection and Real-Time RT-PCR

Yoshio Ando, Yideng Liang, Shinsuke Ishigaki, Jun-ichi Niwa, Yuemei Jiang, Yasushi Kobayashi, Masahiko Yamamoto, Manabu Doyu, Gen Sobue

Journal:

Neurochemical Research

Year:

2003

Language:

english

File:

PDF, 881 KB

english, 2003

35

Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity

Shinsuke Ishigaki, Jun-ichi Niwa, Shin-ichi Yamada, Miho Takahashi, Takashi Ito, Jun Sone, Manabu Doyu, Fumihiko Urano, Gen Sobue

Journal:

Neurobiology of Disease

Year:

2007

Language:

english

File:

PDF, 1.65 MB

english, 2007

36

Hsp70 and Hsp40 improve neurite outgrowth and suppress intracytoplasmic aggregate formation in cultured neuronal cells expressing mutant SOD1

Hideyuki Takeuchi, Yasushi Kobayashi, Tsuyoshi Yoshihara, Jun-ichi Niwa, Manabu Doyu, Kenzo Ohtsuka, Gen Sobue

Journal:

Year:

2002

Language:

english

File:

PDF, 893 KB

english, 2002

37

Differential temporal expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFRα, LIFRβ, IL-6Rα and gp130) in injured peripheral nerves

Yasuhiro Ito, Masahiko Yamamoto, Mei Li, Manabu Doyu, Fumiaki Tanaka, Tatsuro Mutch, Terunori Mitsuma, Gen Sobue

Journal:

Year:

1998

Language:

english

File:

PDF, 255 KB

english, 1998

38

Caspase-3 Cleaves the Expanded Androgen Receptor Protein of Spinal and Bulbar Muscular Atrophy in a Polyglutamine Repeat Length-Dependent Manner

Yasushi Kobayashi, Shigeru Miwa, Diane E. Merry, Akito Kume, Li Mei, Manabu Doyu, Gen Sobue

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 1.34 MB

english, 1998

39

Two Novel Genes, Human neugrin and Mouse m-neugrin, Are Upregulated with Neuronal Differentiation in Neuroblastoma Cells

Shinsuke Ishigaki, Jun-ichi Niwa, Tsuyoshi Yoshihara, Norimasa Mitsuma, Manabu Doyu, Gen Sobue

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 446 KB

english, 2000

40

A Novel Centrosomal RING-Finger Protein, Dorfin, Mediates Ubiquitin Ligase Activity

Jun-ichi Niwa, Shinsuke Ishigaki, Manabu Doyu, Toshiaki Suzuki, Keiji Tanaka, Gen Sobue

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 688 KB

english, 2001

41

Pathogenesis, animal models and therapeutics in Spinal and bulbar muscular atrophy (SBMA)

Masahisa Katsuno, Hiroaki Adachi, Masahiro Waza, Haruhiko Banno, Keisuke Suzuki, Fumiaki Tanaka, Manabu Doyu, Gen Sobue

Journal:

Experimental Neurology

Year:

2006

Language:

english

File:

PDF, 481 KB

english, 2006

42

A sodium channel myotonia due to a novel SCN4A mutation accompanied by acquired autoimmune myasthenia gravis

Yosuke Kokunai, Keigo Goto, Tomoya Kubota, Takaaki Fukuoka, Saburo Sakoda, Tohru Ibi, Manabu Doyu, Hideki Mochizuki, Ko Sahashi, Masanori P. Takahashi

Journal:

Neuroscience Letters

Year:

2012

Language:

english

File:

PDF, 731 KB

english, 2012

43

Dorfin Localizes to the Ubiquitylated Inclusions in Parkinson's Disease, Dementia with Lewy Bodies, Multiple System Atrophy, and Amyotrophic Lateral Sclerosis

Nozomi Hishikawa, Jun-ichi Niwa, Manabu Doyu, Takashi Ito, Shinsuke Ishigaki, Yoshio Hashizume, Gen Sobue

Journal:

The American Journal of Pathology

Year:

2003

Language:

english

File:

PDF, 1.22 MB

english, 2003

44

Nonneural Nuclear Inclusions of Androgen Receptor Protein in Spinal and Bulbar Muscular Atrophy

Mei Li, Yuji Nakagomi, Yasushi Kobayashi, Dianne E. Merry, Fumiaki Tanaka, Manabu Doyu, Terunori Mitsuma, Yoshio Hashizume, Kenneth H. Fischbeck, Gen Sobue

Journal:

The American Journal of Pathology

Year:

1998

Language:

english

File:

PDF, 747 KB

english, 1998

45

Collagen metabolism in the pulps of rat teeth

W.A. Orlowski, J.L. Doyu

Journal:

Archives of Oral Biology

Year:

1976

Language:

english

File:

PDF, 199 KB

english, 1976

46

Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords – screening by molecular indexing and subsequent cDNA microarray analysis

Shinsuke Ishigaki, Jun-ichi Niwa, Yoshio Ando, Tsuyoshi Yoshihara, Ko-ichi Sawada, Manabu Doyu, Masahiko Yamamoto, Kikuya Kato, Yoshihisa Yotsumoto, Gen Sobue

Journal:

Year:

2002

Language:

english

File:

PDF, 128 KB

english, 2002

47

Gene expression profile in Alzheimer’s brain screened by molecular indexing

Manabu Doyu, Ko-ichi Sawada, Norimasa Mitsuma, Jun-ichi Niwa, Makoto Yoshimoto, Yasuyuki Fujii, Gen Sobue, Kikuya Kato

Journal:

Molecular Brain Research

Year:

2001

Language:

english

File:

PDF, 842 KB

english, 2001

48

c-Jun N-terminal kinase pathway mediates Lactacystin-induced cell death in a neuronal differentiated Neuro2a cell line

Chen Sang, Yasushi Kobayashi, Jun Du, Masahisa Katsumo, Hiroaki Adachi, Manabu Doyu, Gen Sobue

Journal:

Molecular Brain Research

Year:

2002

Language:

english

File:

PDF, 1.13 MB

english, 2002

49

Nerve growth factor prevention of aged-rat sympathetic neuron injury by cisplatin, vincristine and taxol – in vitro explant study

Kazuhiro Hayakawa, Takayuki Itoh, Hisayoshi Niwa, Masahiko Yamamoto, Yideng Liang, Manabu Doyu, Gen Sobue

Journal:

Neuroscience Letters

Year:

1999

Language:

english

File:

PDF, 122 KB

english, 1999

50

Testosterone Reduction Prevents Phenotypic Expression in a Transgenic Mouse Model of Spinal and Bulbar Muscular Atrophy

Masahisa Katsuno, Hiroaki Adachi, Akito Kume, Mei Li, Yuji Nakagomi, Hisayoshi Niwa, Chen Sang, Yasushi Kobayashi, Manabu Doyu, Gen Sobue

Journal:

Year:

2002

Language:

english

File:

PDF, 606 KB

english, 2002

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